Capillary gas chromatographic separation of C10–C12 secondary phenylalkanes on modified cyclodextrin stationary phases

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The separation of isomers and enantiomers of branched C10‐C12 phenylalkanes by gas chromatography on fused silica capillary columns coated with some modified β‐ and γ‐cyclodextrins was studied. It was shown that the separation of positional isomers of C10‐C12 phynylalkanes on modified cyclodextrin capillary columns is not better than that on a column coated with modified polyethylene glycol. Differences were found in the enantioselectivity of modified β‐ and γ‐cyclodextrins for the separation of C10‐C12 secondary phenylalkane enantiomers. While alkylderivatives of β‐CDs resolve enantiomers of 3‐phenylalkanes, alkyl derivatives of γ‐CD resolve enantiomers of 2‐phenylalkanes. Since shape selectivity factors of modified cyclodextrins have indicated no inclusion of the considered solutes in cyclodextrin cavities, enantioselective interactions most probably occur on the outer sphere of cyclodextrins.