Key result
Higher TG/HDL-C levels (fourth and fifth quintiles) were associated with a significantly increased risk of major cardiovascular events compared to the second quintile (aHR 3.38 and 2.67, respectively).
Why the study?
Dyslipidemia is common in kidney transplant recipients, prompting analysis of the triglyceride to high-density lipoprotein cholesterol ratio to identify risk factors for major cardiovascular events.
Does a higher TG/HDL-C ratio predict major cardiovascular events in kidney transplant recipients?
Cohort (n=1,301)
No
Does a higher TG/HDL-C ratio predict major cardiovascular events in kidney transplant recipients?
A higher TG/HDL-C ratio at 1 year post-transplantation is an independent predictor of major cardiovascular events in kidney transplant recipients.
Answers are grounded in this paper and cite their sources.
May identify kidney transplant recipients at higher MACE risk; leaves open whether modifying TG/HDL-C alters outcomes.
BACKGROUND: Dyslipidemia is common in kidney transplant (KT) recipients. We analyzed the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) in KT recipients to identify risk factors for major cardiovascular events (MACE). METHODS: We retrospectively included KT recipients with a lipid profile performed 1 year after transplantation. We classified patients according to the TG/HDL-C divided into quintiles. Subsequently, we analyzed the association between TG/HDL-C and MACE, defined as heart failure, coronary artery disease, and cerebrovascular disease confirmed by imaging studies. RESULTS: A total of 1301 KT recipients were enrolled. The median follow-up duration was 7.4 years (interquartile range 4.4-11.1 years). During the follow-up period, 80 (6.2%) patients developed MACE, which included 38 of unstable anginas, 9 of MIs, 19 of heart failures, 18 of cerebral infarcts, and 4 of cerebral hemorrhages. The fourth and fifth quintiles of TG/HDL-C showed a significantly increased risk of MACE [fourth quintile: adjusted hazard ratio (aHR), 3.38; 95% confidence interval (CI) 1.44-7.95; p = 0.005, fifth quintile: aHR, 2.67; 95% CI 1.13-6.30; p = 0.02]) compared to the second quintile of TG/HDL-C. This association is particularly evident in subgroups of non-DM, HTN, no history of CVD, and statin users. CONCLUSIONS: Higher TG/HDL-C levels may be associated with MACE risk in KT recipients.
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Kim et al. (2019) conducted a cohort in Kidney transplant recipients (n=1,301). Ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) vs. Second quintile of TG/HDL-C was evaluated on Major cardiovascular events (MACE), defined as heart failure, coronary artery disease, and cerebrovascular disease (aHR 3.38, 95% CI 1.44-7.95, p=0.005). Higher TG/HDL-C levels (fourth and fifth quintiles) were associated with a significantly increased risk of major cardiovascular events compared to the second quintile (aHR 3.38 and 2.67, respectively).
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