Key result
Metabolic syndrome increased the risk of in-hospital complications after TEVAR, with complication rates rising from 3.1% to 62.5% as the number of MetS criteria increased from 0 to 5.
Why the study?
It was unknown whether and to what extent metabolic syndrome and its components are associated with in-hospital complications in patients with acute type B aortic dissection after TEVAR.
Is metabolic syndrome associated with increased in-hospital complications in patients with acute type B aortic dissection after TEVAR?
Cohort (n=684)
Is metabolic syndrome associated with increased in-hospital complications in patients with acute type B aortic dissection after TEVAR?
p-value: p=<0.05
Metabolic syndrome, particularly its blood pressure component, is independently associated with a higher risk of in-hospital complications following TEVAR for acute type B aortic dissection.
BACKGROUND: This study aimed to explore whether and to what extent metabolic syndrome (MetS) and its components are associated with in-hospital complications in patients with acute type B aortic dissection after thoracic endovascular aortic repair (TEVAR). METHODS: We retrospectively enrolled 684 patients who had undergone TEVAR. Demographic and clinical data were collected and subgroup analysis, mixed-model regression analysis, scoring systems, and receiver operating characteristic (ROC) curve analyses were performed. RESULTS: Overall, 684 inpatients were assigned to the poor outcome (n = 90) or no complications (n = 594) group. Compared to the no complications group, the poor outcome group had a higher incidence of MetS (44 [48.9%] vs. 120 [20.2%], P < 0.05). In the subgroup analysis, in-hospital complications were present in 3.1%, 6.6%, 11.9%, 20.7%, 40.0%, and 62.5% of patients in the 6 groups who met the 0, 1, 2, 3, 4, and 5 MetS diagnostic criteria, respectively. On multivariable logistic regression, hypertension (odds ratio [OR]: 2.680; 95% confidence interval [CI]: 1.571-4.570), type 2 diabetes (OR: 2.135; 95% CI: 1.192-3.824), quartiles of body mass index (OR: 1.801; 95% CI: 1.415-2.291), high-density lipoprotein cholesterol (OR: 0.763; 95% CI: 0.611-0.953), and systolic blood pressure (OR: 1.894; 95% CI: 1.486-2.413) were independent factors for in-hospital complications after adjustment for other risk factors. After adjusting for potential confounding factors, MetS was an independent risk factor for in-hospital complications. We established a scoring system for each component and the area under the ROC curve was 0.664 (95% CI: 0.618-0.710) in all patients, 0.672 (95% CI: 0.595-0.749) in patients with MetS, and 0.610 (95% CI: 0.552-0.667) in patients without MetS, as determined by ROC analysis. CONCLUSIONS: MetS, especially the blood pressure component, confers a greater risk of in-hospital complications in patients with acute type B aortic dissection after TEVAR.
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Niu et al. (2023) conducted a cohort in Acute type B aortic dissection (n=684). Metabolic syndrome vs. Without metabolic syndrome was evaluated on In-hospital complications (p=<0.05). Metabolic syndrome increased the risk of in-hospital complications after TEVAR, with complication rates rising from 3.1% to 62.5% as the number of MetS criteria increased from 0 to 5.
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