Key result
A higher Triglyceride-Glucose (TyG) index was an independent predictor of new-onset atrial fibrillation during hospitalization in STEMI patients following percutaneous coronary intervention (OR 8.884).
Why the study?
The association between the triglyceride-glucose index and new-onset atrial fibrillation in STEMI patients following PCI had not been established.
Does the TyG index predict new-onset atrial fibrillation and long-term mortality in STEMI patients after PCI?
Cohort (n=549)
No
Does the TyG index predict new-onset atrial fibrillation and long-term mortality in STEMI patients after PCI?
Odds Ratio: 8.884 (95% CI 1.57–50.265)
p-value: p=0.014
The TyG index is a useful independent predictor of new-onset atrial fibrillation during hospitalization in STEMI patients undergoing PCI, which correlates with worse long-term survival.
May support TyG-guided NOAF monitoring post-STEMI PCI; leaves open prospective validation and outcome impact.
Background New-onset atrial fibrillation (NOAF) is associated with worse prognostic outcomes in cases diagnosed with ST-segment elevation myocardial infarction (STEMI) patients after percutaneous coronary intervention (PCI). The triglyceride-glucose (TyG) index, as a credible and convenient marker of insulin resistance, has been shown to be predictive of outcomes for STEMI patients following revascularization. The association between TyG index and NOAF among STEMI patients following PCI, however, has not been established to date. Objective To assess the utility of the TyG index as a predictor of NOAF incidence in STEMI patients following PCI, and to assess the relationship between NOAF and long-term all-cause mortality. Methods This retrospective cohort research enrolled 549 STEMI patients that had undergone PCI, with these patients being clustered into the NOAF group and sinus rhythm (SR) group. The predictive relevance of TyG index was evaluated through logistic regression analyses and the receiver operating characteristic (ROC) curve. Kaplan-Meier curve was employed to explore differences in the long-term all-cause mortality between the NOAF and SR group. Results NOAF occurred in 7.7% of the enrolled STEMI patients after PCI. After multivariate logistic regression analysis, the TyG index was found to be an independent predictor of NOAF [odds ratio (OR): 8.884, 95% confidence interval (CI): 1.570–50.265, P = 0.014], with ROC curve analyses further supporting the predictive value of this parameter, which exhibited an area under ROC curve of 0.758 (95% CI: 0.720–0.793, P < 0.001). All-cause mortality rates were greater for patients in the NOAF group in comparison with the SR group over a median 35-month follow-up period (log-rank P = 0.002). Conclusions The TyG index exhibits values as an independent predictor of NOAF during hospitalization, which indicated a poorer prognosis after a relatively long-term follow-up.
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Yang et al. (2022) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) (n=549). Triglyceride-glucose (TyG) index vs. Lower TyG index was evaluated on New-onset atrial fibrillation (NOAF) during hospitalization (OR 8.884, 95% CI 1.570-50.265, p=0.014). A higher Triglyceride-Glucose (TyG) index was an independent predictor of new-onset atrial fibrillation during hospitalization in STEMI patients following percutaneous coronary intervention (OR 8.884).
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