October 15, 1983Biochemical JournalOpen Access

The aggregation of isolated human platelets in the presence of lipoproteins and prostacyclin

View Full Paper

Ask AI

Bookmark

Population

Isolated human platelets from normal subjects

Design

Preclinical

Authors

DHDavid G. HassallUniversity of London JOJames S. OwenThe Royal Free Hospital KBK. Richard BruckdorferSt George's, University of London

Discussion

Member takes

Implication

May heighten thrombosis risk in hyperlipidemia; leaves open translation from isolated platelets to human outcomes.

Structured PICO

Population

Isolated human platelets from normal subjects

Intervention

Addition of lipoproteins (LDL, HDL, VLDL) and prostacyclin (PGI2)

Outcome

Platelet aggregation in response to ADP and adrenalinesurrogate

LDL sensitizes isolated human platelets to aggregation and overcomes the inhibitory effect of prostacyclin, suggesting a role for LDL in regulating platelet function relevant to cardiovascular disease.

Cite This Study

Hassall et al. (1983) studied this question.

synapsesocial.com/papers/6a85b980c006613b201af0e7 https://doi.org/10.1042/bj2160043

View Full Paper

Ask AI

Bookmark