January 1, 1979Thrombosis and Haemostasis

Aggregation of Gel-Filtered Guinea-Pig Platelets by Lipoproteins

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Population

Gel-filtered platelets (GFP) and platelet-rich plasma from guinea-pigs

Design

Preclinical

Authors

BFBuichi FujitaniSumitomo Dainippon Pharma (Japan)TTToshimichi TsuboiNagoya University KYKouichi YoshidaTokyo University of Technology

Discussion

Member takes

Implication

Lipoprotein effects on platelets merit mechanistic follow-up; hypothesis-generating in this animal model, should not change practice.

Structured PICO

Population

Gel-filtered platelets (GFP) and platelet-rich plasma from guinea-pigs

Intervention

Very low density lipoproteins (VLDL) and low density lipoproteins (LDL) isolated from serum of hypercholesterolemic guinea-pigs

Outcome

Platelet aggregationsurrogate

Lipoproteins (VLDL and LDL) can induce and potentiate platelet aggregation in gel-filtered guinea-pig platelets, likely by modulating platelets to release endogenous ADP.

Cite This Study

Fujitani et al. (1979) studied this question.

synapsesocial.com/papers/6a99e4cb6cf138e929de8944 https://doi.org/10.1055/s-0038-1646790

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