Key result
Thermodilution and indirect Fick cardiac output measurements in LVAD patients showed substantial discordance (45.9%) and a bias of -0.72 L/min, with wide limits of agreement (-3.12 to 1.68 L/min).
Population
Patients supported with a left ventricular assist device undergoing right heart catheterization
Comparison
Cardiac output assessment by thermodilution (TD) vs Cardiac output assessment by indirect Fick method
Design
Cross-sectional
Authors
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Discordance cautions against interchangeable use of thermodilution and indirect Fick CO in LVAD patients; hypothesis-generating, prospective validation needed.
Observational (n=111)
Mean Difference: -0.72
Absolute Event Rate: 4.65% vs 5.37%
p-value: p=<0.001
There is substantial discordance (45.9%) between thermodilution and indirect Fick cardiac output measurements in LVAD patients, suggesting these methods may not be interchangeable in this population.
Tehrani et al. (2017) conducted an observational in Left ventricular assist device (LVAD) support (n=111). Thermodilution (TD) cardiac output measurement vs. Indirect Fick (iFK) cardiac output measurement was evaluated on Mean cardiac output (L/min) (bias -0.72 L/min, p=<0.001). Thermodilution and indirect Fick cardiac output measurements in LVAD patients showed substantial discordance (45.9%) and a bias of -0.72 L/min, with wide limits of agreement (-3.12 to 1.68 L/min).
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