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December 20, 2018PLoS ONEOpen Access

At 3 months, there was no statistically significant difference in mean MMAS-8 scores between the intervention and usual care groups (mean difference 0.03, 95% CI -0.23 to 0.29, p=0.40).

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Why the study?

The study evaluated the effectiveness of a tailored health information technology intervention, Talking Prescriptions, to improve medication adherence in a resource-challenged environment.

Does a tailored health information technology driven intervention (Talking Rx) improve medication adherence in adults with CVA or CAD on anti-platelets and statins?

Population

197 adults with CVA or CAD on anti-platelets and statins with mobile phone access

Comparison

Talking Prescriptions intervention vs usual care

Design

Parallel randomized controlled assessor-blinded trial

Follow-up

3 months

Authors

AKAyeesha Kamran KamalWKWardah KhalidAMAbdul Muqeet

Discussion

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Overview

Null result advises against adopting Talking Rx; challenges efficacy of IVR/text interventions for adherence in LMIC CAD/CVA patients.

Structured PICO

Does a tailored health information technology driven intervention (Talking Rx) improve medication adherence in adults with CVA or CAD on anti-platelets and statins?

P
Population
197 adults with diagnosis of cerebrovascular accident (CVA) or coronary artery disease (CAD) diagnosed at least one month before enrollment, on anti-platelets and statins, with access to a mobile phone.
I
Intervention
Daily Interactive Voice Response (IVR) call services regarding specific statin and antiplatelet, daily tailored medication reminders for statin and antiplatelet, and weekly lifestyle modification messages for a period of 3 months.
C
Comparator
Usual care
O
Outcome
Medication adherence to statin and antiplatelets assessed by the 8-item Morisky Medication Adherence scale 8 (MMAS-8) at 3 monthspatient reported

A phone-based medication adherence program using IVR and text messages did not significantly improve self-reported medication adherence at 3 months in patients with CAD or CVA in a low- and middle-income country setting.

Limitations

  • limited follow up
  • early study

Cite This Study

Kamal et al. (2018) studied this question.

synapsesocial.com/papers/6a85bba88018c50ef23db326https://doi.org/10.1371/journal.pone.0197671
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Using a tailored health information technology- driven intervention to improve health literacy and medication adherence in a Pakistani population with vascular disease (Talking Rx) – study protocol for a randomized controlled trial2016 · 17 citations
  2. 2An Intervention to Improve Medication Adherence in People With Heart Disease (Text4HeartII): Randomized Controlled Trial2021 · 33 citations
  3. 3Text Messages to Improve Medication Adherence and Secondary Prevention After Acute Coronary Syndrome: The TEXTMEDS Randomized Clinical Trial2022 · 94 citations
  4. 4Telehealth and challenges of statin adherence in patients with diabetes: a randomized controlled trial2025
  5. 5Effects of Telephone Counseling Intervention by Pharmacists (TelCIP) on Medication Adherence; Results of a Cluster Randomized Trial2016 · 48 citations