January 1, 2010Journal of Lipid ResearchOpen Access

Expression of apolipoprotein C-III in McA-RH7777 cells enhances VLDL assembly and secretion under lipid-rich conditions

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Population

McA-RH7777 cells

Comparison

Stable expression of recombinant apolipoprotein… vs Lipid-poor conditions or cells without the…

Design

Preclinical

Authors

MSMeenakshi SundaramBiotechnology Research Center SZShumei ZhongChina National Pharmaceutical Group Corporation (China)MKMaroun Bou KhalilUniversity of Ottawa

Discussion

Member takes

Implication

May influence VLDL production in lipid-rich states; leaves open therapeutic implications for apoC-III inhibition pending in vivo confirmation.

Structured PICO

Population

McA-RH7777 cells

Intervention

Stable expression of recombinant apolipoprotein C-III (apoC-III) and introduction of an Ala23-to-Thr mutation

Comparator

Lipid-poor conditions or cells without the mutation

Outcome

VLDL-associated triacylglycerol (TAG) and apoB-100 secretion efficiencysurrogate

Expression of apoC-III enhances hepatic TAG-rich VLDL assembly and secretion under lipid-rich conditions, highlighting its intracellular role in lipid metabolism.

Cite This Study

Sundaram et al. (2010) studied this question.

synapsesocial.com/papers/6a85bc0d581d4f62e2d5b900 https://doi.org/10.1194/jlr.m900346-jlr200

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Implication

May influence VLDL production in lipid-rich states; leaves open therapeutic implications for apoC-III inhibition pending in vivo confirmation.

Expression of apolipoprotein C-III in McA-RH7777 cells enhances VLDL assembly and secretion under lipid-rich conditions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Expression of apolipoprotein C-III in McA-RH7777 cells enhances VLDL assembly and secretion under lipid-rich conditions

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider