Why the study?
Does apolipoprotein CIII induce expression of adhesion molecules in vascular endothelial cells and increase adhesion of monocytic cells?
Population
Vascular endothelial cells (ECs) and human monocytic THP-1 cells
Comparison
Treatment with apolipoprotein CIII or… vs Control
Design
Preclinical
Authors
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ApoCIII may promote endothelial activation in preclinical models; leaves open its role in human atherogenesis.
Does apolipoprotein CIII induce expression of adhesion molecules in vascular endothelial cells and increase adhesion of monocytic cells?
ApoCIII directly activates vascular endothelial cells by increasing VCAM-1 and ICAM-1 expression via PKCbeta and NF-kappaB pathways, promoting monocyte adhesion and potentially contributing to atherogenesis.
Kawakami et al. (2006) studied this question.
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