Population
Mutants of the microorganism Dictyostelium discoideum
Design
Preclinical
Authors
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Extends cGMP-myosin signaling to osmotic adaptation in a model organism; leaves open relevance to human cardiomyocyte stress responses.
Demonstrates that cGMP-mediated myosin phosphorylation allows Dictyostelium discoideum to resist osmotic stress by redistributing myosin and adopting a spherical shape.
Kuwayama et al. (1996) studied this question.
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