Population
Dictyostelium discoideum myosin heavy chain fragments
Comparison
Replacement of threonine residues by serine and… vs Normal (wild-type) fragments
Design
Preclinical
Authors
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Advances knowledge of myosin regulation in model systems; leaves open relevance to cardiac myosin function in mammals.
Identified a new phosphorylation site in the Dictyostelium myosin II heavy chain and demonstrated that the kinases can accept serine in place of threonine given the correct structural context.
Lück-Vielmetter et al. (1990) studied this question.
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