January 25, 2000FEBS LettersOpen Access

Mutational analysis of phosphorylation sites in the Dictyostelium myosin II tail: disruption of myosin function by a single charge change

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Population

Dictyostelium discoideum myosin II

Design

Preclinical

Authors

Discussion

A single charge change at 1823 disrupts myosin function in Dictyostelium; leaves open relevance to human cardiac myosin regulation.

Population

Dictyostelium discoideum myosin II

Intervention

Systematic replacement of three threonines (1823, 1833, and 2029) to aspartates in the myosin II tail

Outcome

Myosin filament assembly and in vivo functionsurrogate

A single charge change at position 1823 in the Dictyostelium myosin II tail is sufficient to disrupt myosin filament formation and in vivo function.

Nock et al. (2000) studied this question.

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