Why the study?
Does the addition of a heterophile blocking reagent reduce spuriously elevated CK-MB concentrations caused by human anti-murine antibodies?
Population
19 surgical patients with colorectal carcinoma who had received injections of an 125I-labeled murine…
Comparison
Addition of a heterophile blocking reagent to… vs Serum specimens before addition of blocking…
Design
Case_series
Authors
Loading...
May avert false CK-MB elevations in murine antibody recipients; hypothesis-generating and should not yet change practice.
Does the addition of a heterophile blocking reagent reduce spuriously elevated CK-MB concentrations caused by human anti-murine antibodies?
Heterophile antibodies can cause spuriously elevated CK-MB levels in patients receiving murine monoclonal antibodies, which can be corrected using a heterophile blocking reagent to prevent misdiagnosis of myocardial ischemia.
Sosolik et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: