Effects of metoprolol vs verapamil in patients with stable angina pectoris: The Angina Prognosis Study in Stockholm (APSIS)

March 1, 1996European Heart JournalOpen Access

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Key Points

To compare the prognostic and antianginal effects of treatment with metoprolol versus verapamil in patients diagnosed with stable angina pectoris.
Conducted the Angina Prognosis Study in Stockholm (APSIS) in patients presenting with stable angina pectoris.
Assigned participants to treatment with either the beta-adrenoceptor antagonist metoprolol or the calcium channel blocker verapamil.
Evaluated the incidence of major cardiovascular events and overall prognosis between the metoprolol and verapamil treatment arms.
Demonstrated comparable antianginal efficacy and long-term cardiovascular safety profiles for both therapeutic strategies in stable angina pectoris.

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Reveals comparative cardiovascular outcomes between metoprolol and verapamil in stable angina pectoris, highlighting optimal antianginal therapies.

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Rehnqvist et al. (1996) studied this question.

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