January 12, 1986Acta Medica Scandinavica

Reduction of Nonfatal Reinfarctions in Patients with a History of Hypertension by Chronic Postinfarction Treatment with Metoprolol

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Why the study?

Does metoprolol reduce fatal and nonfatal events in postmyocardial infarction patients with a history of hypertension?

Population

76 postmyocardial infarction patients with a history of treatment for hypertension prior to the index…

Comparison

Metoprolol 100 mg b.i.d. for three years vs Matching placebo for three years

Design

RCT, double-blind

Follow-up

three years

Authors

GOGunnar OlssonKarolinska Institutet NRNina RehnqvistUniversity of Udine

Discussion

Member takes

Implication

Supports metoprolol post-MI in hypertensives to cut events; extends beta-blocker evidence to this subgroup.

Structured PICO

Does metoprolol reduce fatal and nonfatal events in postmyocardial infarction patients with a history of hypertension?

Population

76 postmyocardial infarction patients with a history of treatment for hypertension prior to the index infarction (subgroup of a 301-patient trial)

Intervention

Metoprolol 100 mg b.i.d. for three years

Comparator

Matching placebo for three years

Outcome

Fatal and nonfatal events (death, reinfarction, coronary artery bypass surgery, cerebrovascular events, lower limb amputation) over three yearshard clinical

Chronic postinfarction treatment with metoprolol significantly reduces nonfatal atherosclerotic complications, particularly reinfarctions, in patients with a history of hypertension.

Limitations

retrospective subgroup analysis

Cite This Study

Olsson et al. (1986) studied this question.

synapsesocial.com/papers/6a75fd707d7eb453cc707ae3 https://doi.org/10.1111/j.0954-6820.1986.tb02727.x

Topics

Hypertension management

View Full Paper

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January 12, 1986Acta Medica Scandinavica

Reduction of Nonfatal Reinfarctions in Patients with a History of Hypertension by Chronic Postinfarction Treatment with Metoprolol

View Full Paper

Ask AI

Bookmark

Why the study?

Does metoprolol reduce fatal and nonfatal events in postmyocardial infarction patients with a history of hypertension?

Population

76 postmyocardial infarction patients with a history of treatment for hypertension prior to the index…

Comparison

Metoprolol 100 mg b.i.d. for three years vs Matching placebo for three years

Design

RCT, double-blind

Follow-up

three years

Authors

GOGunnar OlssonKarolinska Institutet NRNina RehnqvistUniversity of Udine

Discussion

Member takes

Implication

Supports metoprolol post-MI in hypertensives to cut events; extends beta-blocker evidence to this subgroup.

Structured PICO

Does metoprolol reduce fatal and nonfatal events in postmyocardial infarction patients with a history of hypertension?

Population

76 postmyocardial infarction patients with a history of treatment for hypertension prior to the index infarction (subgroup of a 301-patient trial)

Intervention

Metoprolol 100 mg b.i.d. for three years

Comparator

Matching placebo for three years

Outcome

Fatal and nonfatal events (death, reinfarction, coronary artery bypass surgery, cerebrovascular events, lower limb amputation) over three yearshard clinical

Chronic postinfarction treatment with metoprolol significantly reduces nonfatal atherosclerotic complications, particularly reinfarctions, in patients with a history of hypertension.

Limitations

retrospective subgroup analysis

Cite This Study

Olsson et al. (1986) studied this question.

synapsesocial.com/papers/6a75fd707d7eb453cc707ae3 https://doi.org/10.1111/j.0954-6820.1986.tb02727.x

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Hypertension management

View Full Paper

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