January 12, 1988Acta Medica Scandinavica
Effects on Mortality during Five Years after Early Intervention with Metoprolol in Suspected Acute Myocardial Infarction
Why the study?
Does early intervention with metoprolol reduce mortality in patients with suspected acute myocardial infarction?
Population
1,395 patients with suspected acute myocardial infarction
Comparison
Metoprolol 200 mg daily for the first 3 months… vs Placebo for the first 3 months, followed by…
Design
RCT, randomized, double-blind
Follow-up
5 years
Authors
Discussion
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Implication
No sustained 5-year mortality benefit with early metoprolol in suspected AMI; confirms attenuation once background therapy equalizes.
Structured PICO
Does early intervention with metoprolol reduce mortality in patients with suspected acute myocardial infarction?
P
Population
1,395 patients with suspected acute myocardial infarction
I
Intervention
Metoprolol 200 mg daily for the first 3 months, followed by similar treatment implying beta-blockade to a majority
C
Comparator
Placebo for the first 3 months, followed by similar treatment implying beta-blockade to a majority
O
Outcome
Mortality over a 5-year periodhard clinical
Early intervention with metoprolol in suspected acute myocardial infarction reduces mortality up to 2 years, but this survival benefit is attenuated by 5 years when both groups subsequently receive similar beta-blocker therapy.
Cite This Study
Herlitz et al. (1988) studied this question.