Key result
Early metoprolol shows no 1-year mortality benefit over placebo in suspected acute MI.
Why the study?
The long-term prognosis after early intervention with metoprolol in suspected acute myocardial infarction was uncertain.
Does early intravenous metoprolol followed by oral treatment reduce mortality in patients with suspected acute myocardial infarction?
Population
5778 patients with suspected acute myocardial infarction
Comparison
Early intravenous metoprolol followed by oral treatment for 15 days vs placebo
Design
Randomized controlled trial
Follow-up
1 year
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No mortality benefit from early metoprolol in suspected AMI; challenges hypothesis of prognostic improvement.
RCT (n=5,778)
Does early intravenous metoprolol followed by oral treatment reduce mortality in patients with suspected acute myocardial infarction?
Absolute Event Rate: 10.6% vs 10.7%
p-value: p=>0.2
Early intervention with metoprolol in suspected acute myocardial infarction did not improve long-term prognosis compared to placebo.
A 1991 study conducted an RCT in suspected acute myocardial infarction (n=5,778). metoprolol vs. placebo was evaluated on mortality (p=>0.2). Early intervention with metoprolol in suspected acute myocardial infarction did not improve 1-year mortality compared to placebo (10.6% vs 10.7%, P>0.2).
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