Why the study?
Does very early intervention with metoprolol reduce overall mortality in patients with suspected acute myocardial infarction?
Population
800 patients with suspected acute myocardial infarction
Comparison
Metoprolol 15 mg I.V. followed by oral… vs Control group
Design
RCT, randomized, double blind
Follow-up
12 months
Authors
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Very early metoprolol does not reduce total mortality in suspected AMI; challenges routine pre-hospital beta-blockade despite fewer sudden deaths.
Does very early intervention with metoprolol reduce overall mortality in patients with suspected acute myocardial infarction?
Very early intervention with IV followed by oral metoprolol in suspected acute myocardial infarction does not significantly reduce total mortality up to 12 months, despite a reduction in sudden death.
Salathia et al. (1985) studied this question.
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