November 1, 1998Anesthesia & Analgesia

Prolonged Paralysis After a Test Dose of Mivacurium in a Patient with Atypical Serum Cholinesterase

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Population

19-year-old female patient with hyperhidrosis scheduled for elective bilateral thoracoscopic…

Design

Case_report

Follow-up

Approximately 7.5 hours post-administration

Authors

LVLuc E. VanlinthoutRadboud University Nijmegen CBCynthia F. BartelsUniversity of Nebraska at Omaha OLOksana LockridgeNebraska Medical Center

Discussion

Member takes

Implication

Prompts caution with mivacurium test doses in suspected atypical cholinesterase cases; leaves open validation in larger cohorts.

Structured PICO

Population

19-year-old female patient (n=1) with hyperhidrosis scheduled for elective bilateral thoracoscopic sympathicolysis, known to be homozygous for the atypical serum cholinesterase gene (A/AK genotype).

Intervention

Mivacurium 14 µg/kg IV bolus (test dose) administered during anesthesia.

Outcome

Duration of neuromuscular blockade and time to recovery of neuromuscular transmission.safety

Even a very small test dose of mivacurium (14 µg/kg) can cause unexpectedly prolonged and intense neuromuscular blockade in patients homozygous for atypical serum cholinesterase.

Cite This Study

Vanlinthout et al. (1998) studied this question.

synapsesocial.com/papers/6a85c49e581d4f62e2d5bab6 https://doi.org/10.1213/00000539-199811000-00042

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Prolonged Paralysis After a Test Dose of Mivacurium in a Patient with Atypical Serum Cholinesterase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Prolonged Paralysis After a Test Dose of Mivacurium in a Patient with Atypical Serum Cholinesterase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider