Key result
In children aged 2-10 years, the ED50 and ED95 of mivacurium were 52 and 89 mcg/kg during halothane anesthesia, and 62 and 103 mcg/kg during narcotic anesthesia.
Why the study?
What are the dose-response relationships and recovery profiles of mivacurium in children during different anesthetic backgrounds?
Population
Children (2-10 years) undergoing anesthesia
Comparison
Mivacurium single bolus doses of 20-120… vs Nitrous oxide-halothane anesthesia versus…
Design
Other
Authors
Loading...
Offers initial pediatric dose-response data for mivacurium; leaves open larger trials to guide practice.
What are the dose-response relationships and recovery profiles of mivacurium in children during different anesthetic backgrounds?
Mivacurium provides effective neuromuscular blockade in children with dose requirements slightly lower during halothane compared to narcotic anesthesia.
Sarner et al. (1989) studied Children undergoing anesthesia (n=90). Mivacurium chloride (BW B1090U) vs. Nitrous oxide-halothane vs nitrous oxide-narcotic anesthesia was evaluated on ED50 and ED95 for neuromuscular blockade. In children aged 2-10 years, the ED50 and ED95 of mivacurium were 52 and 89 mcg/kg during halothane anesthesia, and 62 and 103 mcg/kg during narcotic anesthesia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: