What question did this study set out to answer?

This study aims to establish the median effective dose (ED50) and 95% effective dose (ED95) of mivacurium to maintain motor evoked potentials (MEPs) during scoliosis surgery.

June 10, 2026Drug Design Development and TherapyOpen Access

Mivacurium Infusion ED50/ED95 for Maintaining Motor Evoked Potentials During Adolescent Scoliosis Surgery Under TIVA: A Modified Dixon Up-and-Down Sequential Dose-Finding Study

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Authors

YZYixuan ZhangNanchang University SZShuhan ZhangShanghai Changzheng Hospital HWHuawei WeiShanghai Changzheng Hospital

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Implication

Randomized trial determines effective mivacurium doses for motor evoked potentials in adolescents undergoing surgery, suggesting safety during monitoring.

Key Points

This study aims to establish the median effective dose (ED50) and 95% effective dose (ED95) of mivacurium to maintain motor evoked potentials (MEPs) during scoliosis surgery.
Conducted a modified Dixon up-and-down sequential dose-finding trial with 26 adolescents undergoing scoliosis surgery.
Administered continuous mivacurium infusion while monitoring MEP under total intravenous anesthesia.
Established ED50 and ED95 through Probit analysis based on MEP waveform presence.
ED50 was determined to be 7.24 μg·kg − 1 ·min − 1 (95% CI: 6.87–7.54).
ED95 was found to be 6.70 μg·kg − 1 ·min − 1 (95% CI: 4.79–6.99).
No serious adverse events reported; hemodynamic parameters remained stable.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a28fff36f82f25be989cbda https://doi.org/10.2147/dddt.s581844

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Implication

Randomized trial determines effective mivacurium doses for motor evoked potentials in adolescents undergoing surgery, suggesting safety during monitoring.

Mivacurium Infusion ED50/ED95 for Maintaining Motor Evoked Potentials During Adolescent Scoliosis Surgery Under TIVA: A Modified Dixon Up-and-Down Sequential Dose-Finding Study

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Key Points

Cite This Study

Mivacurium Infusion ED50/ED95 for Maintaining Motor Evoked Potentials During Adolescent Scoliosis Surgery Under TIVA: A Modified Dixon Up-and-Down Sequential Dose-Finding Study

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Key Points

Cite This Study

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