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After a single dose of reserpine (1 mg/kg intravenously) to rabbits the symptoms appeared when most of the monoamines still were present in brain and heart. In long‐term reserpine treated rabbits (0.2 mg/kg subcutaneously daily for more than 8 weeks) the monoamine metabolism was studied with respect to normetanephrine, homovanillic acid and 5‐hydroxyindoleacetic acid. In the chronically treated animals the deaminated metabolites appeared essentially as after a single dose of reserpine whereas normetanephrine showed a slower recovery in the chronically treated animals. Gross inspection of behaviour and sympathetic activity following DOPA injection revealed no clearcut changes in the response to DOPA in rabbits chronically treated with reserpine compared to normal animals.
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Häggendal et al. (1967) studied this question.
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