Study of the Relationship Between the Neurotransmitter Store and Adrenergic Nerve Block Induced by Reserpine and Guanethidine
Authors
Discussion
Loading...
Member takes
Implication
Does not support altering clinical adrenergic blockade based on canine data; leaves open translation of depletion thresholds to humans.
Key Points
- This research aims to explore how neurotransmitter storage affects adrenergic nerve blockade by reserpine and guanethidine.
- Intravenous injection of 3 mg/kg reserpine or 10 mg/kg guanethidine in dogs.
- Measurement of heart rate response to cardioaccelerator nerve stimulation and myocardial norepinephrine levels at various time intervals.
- Observation of norepinephrine infusion effects on heart rate response post-treatment.
- Guanethidine caused complete blockade of heart rate response before any measurable norepinephrine depletion.
- Reserpine only reduced heart rate response after norepinephrine levels dropped to 0.3 µg/g.
- Norepinephrine infusion did not restore heart rate response in either treatment group.
Cite This Study
Gaffney et al. (1963) studied this question.