Population
Heart-lung preparations made from normal and chronically reserpinized dogs
Comparison
Guanethidine and bretylium vs Effects compared between untreated preparations…
Design
Preclinical
Authors
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These in vitro effects caution against clinical extrapolation; leaves open mechanistic questions for intact models and future studies.
Guanethidine and bretylium exert initial positive inotropic and chronotropic effects partly via catecholamine release, with distinct intrinsic effects in amine-depleted hearts.
Tom E. Gaffney (1961) studied this question.
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