Effects of Reserpine and Guanethidine on Venous Reflexes
Why the study?
Do reserpine and guanethidine block reflex venoconstriction in anesthetized dogs?
Population
18 open-chest anesthetized dogs
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May explain antihypertensive effects via venoconstriction blockade in dogs; leaves open translation to human therapy.
Structured PICO
Do reserpine and guanethidine block reflex venoconstriction in anesthetized dogs?
P
Population
18 open-chest anesthetized dogs
I
Intervention
Guanethidine (10 mg/kg IV acutely or over two days) or Reserpine (0.5 mg/kg IV acutely or IP over two days)
O
Outcome
Reflex venoconstriction following carotid occlusion and central vagal stimulationsurrogate
Both reserpine and guanethidine abolish reflex venoconstriction in dogs, suggesting this mechanism may contribute to their antihypertensive effects.
Cite This Study
Gaffney et al. (1962) studied this question.