In view of the pronounced influence of polar groups in the molecule in determining the specificity of protein antigens, it might be expected that the phosphate groups in natural and artificial phospho- proteins would be largely responsible for the im- munological specificity of these proteins. Investiga- tion of their serological properties might therefore yield useful information about the structure, and the biosynthesis, of natural phosphoproteins.
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Gregory Francis (1952) studied this question.
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