Why the study?
Pulmonary hypertension secondary to heart failure combined with pulmonary vascular remodeling carries high mortality, and apolipoprotein A1 adversely affects outcomes in heart failure.
Do lower ApoA1 levels predict adverse clinical outcomes and pulmonary vascular remodeling in patients with pulmonary hypertension secondary to heart failure?
Population
175 patients with HF-PH who underwent right heart catheterization
Comparison
Lower ApoA1 levels (<=1.025 g/L) vs higher ApoA1 levels
Design
Prospective follow-up study
Follow-up
Average of 4.4 years
Authors
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Lower ApoA1 may aid risk stratification in HF-PH; hypothesis-generating for its role in CpcPH and survival, needing prospective validation.
Do lower ApoA1 levels predict adverse clinical outcomes and pulmonary vascular remodeling in patients with pulmonary hypertension secondary to heart failure?
Lower ApoA1 levels are an independent risk factor for pulmonary vascular remodeling and reduced survival in patients with pulmonary hypertension secondary to heart failure.
Yu et al. (2022) studied this question.
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