Why the study?
Does amiodarone treatment cause hepatotoxicity in patients with cardiac tachyarrhythmias?
Does amiodarone treatment cause hepatotoxicity in patients with cardiac tachyarrhythmias?
Amiodarone can cause severe hepatic injury, necessitating regular screening of hepatic enzymes and discontinuation if cholestatic injury or hepatomegaly is suspected.
Amiodarone hepatotoxicity warrants monitoring in arrhythmia patients; leaves open optimal surveillance frequency and risk stratification in contemporary cohorts.
Amiodarone has proved very effective in the treatment of otherwise resistant cardiac tachyarrhythmias. The use of amiodarone has, however, been limited due to its serious side-effects. A patient with cholestatic hepatitis due to amiodarone treatment is presented below and a review of the hepatotoxicity of amiodarone is given. It is concluded that solid evidence exists of hepatic injury due to amiodarone treatment, including steatosis, alterations resembling alcoholic hepatitis, cholestatic hepatitis and micronodular cirrhosis of the liver. Patients receiving amiodarone should be regularly screened with respect to hepatic enzyme levels. Therapy should be discontinued on the suspicion of cholestatic injury or hepatomegaly.
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Jüri Johannes Rumessen (1986) studied this question.
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