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January 2, 1989Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy

Hepatotoxicity Associated with Amiodarone Therapy

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Why the study?

What are the hepatotoxic effects associated with amiodarone therapy?

Population

Patients receiving amiodarone therapy

Design

Case_report

Authors

KFKristen K. FlahartySCSandra L. ChaseHYHarout Yaghsezian

Discussion

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Overview

Supports LFT monitoring with amiodarone; case reports leave fatal hepatotoxicity incidence uncertain.

Structured PICO

What are the hepatotoxic effects associated with amiodarone therapy?

P
Population
Patients receiving amiodarone therapy
I
Intervention
Amiodarone
O
Outcome
Hepatotoxicitysafety

Amiodarone therapy is associated with a spectrum of hepatotoxicity ranging from asymptomatic liver function test elevations to fatal hepatic disease.

Cite This Study

Flaharty et al. (1989) studied this question.

synapsesocial.com/papers/6a94deaa5426d440e59e5908https://doi.org/10.1002/j.1875-9114.1989.tb04102.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adverse reactions during treatment with amiodarone hydrochloride.1983 · 154 citations
  2. 2Side effects of long-term amiodarone therapy.1983 · 359 citations
  3. 3Amiodarone: clinical efficacy and toxicity in 96 patients with recurrent, drug-refractory arrhythmias.1983 · 266 citations
  4. 4Clinical pharmacokinetics and efficacy of amiodarone for refractory tachyarrhythmias.1983 · 240 citations
  5. 5Advances in Antiarrhythmic Therapy1982 · 21 citations