The Vitamin D Endocrine System and the Hematolymphopoietic Tissue

This is the authors' abstract. We don't add key points for this paper.

Editorials1 January 1984The Vitamin D Endocrine System and the Hematolymphopoietic TissueSTAVROS C. MANOLAGAS, M.D., PH.D, LEONARD J. DEFTOS, M.D.STAVROS C. MANOLAGAS, M.D., PH.DSearch for more papers by this author, LEONARD J. DEFTOS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-1-144 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe importance of 1,25 dihydroxyvitamin D3(calcitriol), the hormone formed from two hydroxylations of the parent vitamin D, on mineral and skeletal metabolism is well established. The mineralotropic effects of calcitriol are produced in the classic target organs of vitamin D: intestine, bone, and kidney. However, the identification of several additional target organs for calcitriol has shown that this hormone regulates many more tissues and that its role in biology extends far beyond its classically regarded role in mineral metabolism. A rapidly increasing body of evidence suggests that calcitriol is involved with the hematolymphopoietic tissue, and new theoretical and clinical...References1. BRESLAUMCGUIREZERWEKHFRENKELPAK NJJEC. Hypercalcemia associated with increased serum calcitriol in three patients with lymphoma. Ann Intern Med. 1984;100:1-7. LinkGoogle Scholar2. MASONFRANKELCHANLISSNERPOSEN RTYDS. Vitamin D conversion by sarcoid lymph node homogenate. Ann Intern Med 1984;100:59-61. LinkGoogle Scholar3. TURNERHOWARDPUZASBAYLINKKNAPP RGJDD. Calvarial cells synthesize 1 α, 25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3. Biochemistry. 1983;22:1073-6. CrossrefMedlineGoogle Scholar4. URISTMCLEAN MF. Mast cells in bones. Surg Forum. 1956;7:590-9. Google Scholar5. YETGINOZSOYLU SS. Myeloid metaplasia in vitamin D deficiency rickets. Scand J Haematol. 1982;28:180-5. CrossrefMedlineGoogle Scholar6. STRODER J. Immunity in vitamin D-deficient rickets. In: NORMAN AW, ed. Vitamin D and Problems Related to Uremic Bone Disease. Berlin: De Gruyter; 1975, 675-87. Google Scholar7. LORENTEFONTANJARACASAGARCIA-RODRIGUEZOJEDA FGPCMJ. Defective neutrophil motility in hypovitaminosis D rickets. Acta Paediatr Scand. 1976;65:695-9. CrossrefMedlineGoogle Scholar8. STRÖDERKASAL JP. Evaluation of phagocytosis in rickets. Acta Paediatr Scand. 1970;65:288-92. CrossrefGoogle Scholar9. BAR-SHAVITNOFFEDELSTEINMEYERSHIBOLETGOLDMEN ZDSMSR. 1,25-dihydroxyvitamin D3 and the regulation of macrophage function. Calcif Tissue Int. 1981;33:673-6. CrossrefMedlineGoogle Scholar10. ABEMIYAURASAKAGAMI ECH. Differentiation of mouse myeloid leukemia cells induced by 1α-25-dihydroxyvitamin D3. Proc Natl Acad Sci USA. 1981;78:4990-4. CrossrefMedlineGoogle Scholar11. MIYAURAABEKURIBAYASHI CET. 1α-25-dihydroxyvitamin D3 induces differentiation of human myeloid leukemia cells. Biochem Biophys Res Commun. 1981;102:937-43. CrossrefMedlineGoogle Scholar12. HONMAHOZUMIABE YME. 1α-hydroxyvitamin D3 prolong survival time of mice inoculated with myeloid leukemia cells. Proc Natl Acad Sci USA. 1983;80:201-4. CrossrefMedlineGoogle Scholar13. PROVVEDINITSOUKASMANOLAGASDEFTOS DCSL. 1,25-dihydroxyvitamin D3 receptors in human leukocytes. Science. 1983;221:1181-3. CrossrefMedlineGoogle Scholar14. ABEMIYAURATANAKA ECH. 1α, 25-dihydroxyvitamin D3 promotes fusion of mouse alveolar macrophages both by a direct mechanism and by a spleen cell-mediated indirect mechanism. Proc Natl Acad Sci USA. 1983;80:5583-7. CrossrefMedlineGoogle Scholar15. FALLONTEITELBAUMKAHN MSA. Multinucleation enhances macrophage-mediated bone resorption. Lab Invest. 1983;49:159-64. MedlineGoogle Scholar16. BONUCCI E. New knowledge on the origin, function and fate of osteoclasts. Clin Orthop. 1981;158:252-69. CrossrefGoogle Scholar17. BURGERVAN DER MEERVAN DE GEVELGRIBNAUTHESINGHVAN FURTH EJJJCR. In vitro formation of osteoclasts from long term cultures of bone marrow mononuclear phagocytes. J Exp Med. 1982;156:1604-14. CrossrefMedlineGoogle Scholar18. TEITELBAUMKAHN SA. Mononuclear phagocytes, osteoclasts, and bone resorption. Min Elect Metab. 1980;3:2-9. Google Scholar19. ASHLOUTITTOWNSEND PJK. Osteoclasts derived from haematopoietic stem cells. Nature. 1980;283:669-70. CrossrefMedlineGoogle Scholar20. MUNDYALTMANGONDEKBANDELIN GAMJ. Direct resorption of bone by human monocytes. Science. 1977;196:1109-11. CrossrefMedlineGoogle Scholar21. DOMINGUEZMUNDY JG. Monocytes mediate osteoclastic bone resorption by prostaglandin production. Calcif Tissue Int. 1979;31:29-34. CrossrefGoogle Scholar22. YONEDAMUNDY TG. Monocytes regulate osteoclast-activating factor production by releasing prostaglandins. J Exp Med. 1979;150:338-50 CrossrefMedlineGoogle Scholar23. WANGJEEWOODBURYMATTHEWS TWLJ. Effects of phytohemagglutinin-P (PHA-P) on bone of the growing rat. Metab Bone Dis Rel Res. 1982;4:193-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of California, San Diego Veterans Administration Medical Center La Jolla, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited By1?,25-dihydroxyvitamin D3 inhibits rat liver ultrastructural changes in diethylnitrosamine-initiated and phenobarbital promoted rat hepatocarcinogenesisHepatic expression of regeneration marker genes following partial hepatectomy in the ratAll-trans and 9-cis retinoic acid enhance 1,25-dihydroxyvitamin D3-induced monocytic differentiation of U937 cellsLymphocyte subpopulations in children with vitamin D deficient ricketsDistribution of target cells for 1,25-dihydroxyvitamin D3 in the brain of the yellow bellied turtle Trachemys scriptaTreatment of acute myeloid leukemia in the elderly with low-dose cytarabine, hydroxyurea, and calcitriolSuspected distinct activation pathways of human lymphocytes induced by antilymphocyte globulin and anti-CD 3 monoclonal antibody result in different secretion of hematopoietic colony-stimulating activitiesEffects of Isolation on Interferon Production and Hematological and Immunological ParametersHypercalcemia and vitamin d metabolism in Hodgkin's disease. Is there an underlying immunoregulatory relationship?Vitamin D metabolism in myelomaVitamin D-deficiency rickets and myelofibrosisDemonstration of a high affinity receptor for 1,25-dihydroxyvitamin D3 in rat pancreasTHE CLONING OF THE STEROID HORMONE RECEPTORS: BASIC AND CLINICAL IMPLICATIONSLymphocytic Population and Vitamin DIn vivo effects of 1,25-dihydroxyvitamin D3 and minerals on synthesis of leukotriene B4 and 5-hydroxyeicosatetraenoic acid by rat peritoneal neutrophils6 OsteomalaciaEnhanced suppression of 1,25(OH)2D3 and intact parathyroid hormone in Graves' disease as compared to toxic nodular goiterMyeloid progenitors from the bone marrow of patients with vitamin D resistant rickets (type II) fail to respond to 1,25(OH) 2 D 3Case Report: Granuloma-Related Hypercalcemia in Lipoid PneumoniaMetabolism of 25-hydroxycholecalciferol in a teleost fish, the rainbow trout (Salmo gairdneri)Occult sarcoidosis as the cause of hypercalcemiaHereditäre Störungen des Vitamin-D-StoffwechselsInteractions of 1,25-dihydroxyvitamin D3 and the immune systemEXTRA-ENDOCRINE FUNCTIONS OF VITAMIN DCoupling of bone formation to bone resorption: A broader viewVitamin D and the Lymphomedullary SystemCells Metabolizing Vitamin DMYRON S. COHEN, M.D., T. KENNEY GRAY, M.D. 1 January 1984Volume 100, Issue 1Page: 144-146KeywordsBoneCalcitriolEndocrine systemHormonesKidneysVitamin D Issue Published: 1 January 1984 PDF DownloadLoading ...