HTLV-2 infection of CD14-positive monocyte/macrophage lineage cells and higher proviral loads are associated with predominantly sensory polyneuropathy in HIV-1/HTLV-2 coinfected patients.
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HTLV-2 in CD14+ monocytes linked to sensory polyneuropathy in coinfected patients; leaves open causality and need for longitudinal studies.
We investigated the presence of human T-lymphotropic virus type 2 (HTLV-2) DNA in the peripheral blood mononuclear cell subsets obtained from 18 patients coinfected with human immunodeficiency virus type 1 and HTLV-2, 6 of whom also had predominantly sensory polyneuropathy (PSP). HTLV-2 DNA and RNA were found in CD8- and CD19-positive cells, and, for patients with PSP, in CD14-positive cells as well. Furthermore, the patients with PSP had higher proviral loads than those without PSP.
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Zehender et al. (1998) studied this question.
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