Why the study?
Does metyrapone-induced mineralocorticoid excess combined with sodium replenishment cause hypertension through volume expansion or increased peripheral resistance in dogs?
Population
24 trained, conscious dogs with chronically implanted iliac catheters, maintained on restricted sodium diets
Comparison
Metyrapone treatment combined with gradual… vs Untreated controls submitted to the same sodium…
Design
Preclinical
Authors
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Supports resistance-mediated mechanism in early mineralocorticoid hypertension in dogs; leaves open translation to human disease.
Does metyrapone-induced mineralocorticoid excess combined with sodium replenishment cause hypertension through volume expansion or increased peripheral resistance in dogs?
Mineralocorticoid-induced hypertension in dogs is resistance-mediated from its earliest stages, driven by the restoration of sodium stores rather than volume expansion.
Onoyama et al. (1979) studied this question.
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