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November 4, 2024Thyroid ResearchOpen Access

Losartan is more effective than angiotensin (1–7) in preventing thyroxine-induced renal injury in the rat

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Why the study?

The non-hypertrophic renal effects of Ang II in experimental hyperthyroidism and the potential protective role of Ang 1-7 in thyroxine-induced renal injury remained unknown.

Does losartan, captopril, or Angiotensin 1-7 prevent thyroxine-induced renal injury in rats?

Population

Adult Sprague Dawley rats

Comparison

Vehicle vs T4 vs T4 plus Ang 1-7 vs T4 plus captopril vs T4 plus losartan

Design

Animal experimental study across 5 groups

Authors

SMSlava MalatialiKuwait UniversityMOMabayoje A. OriowoKuwait University

Discussion

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Implication

Losartan may attenuate thyroxine-related renal injury in rats; leaves open any role for RAS modulation in human hyperthyroidism.

Structured PICO

Does losartan, captopril, or Angiotensin 1-7 prevent thyroxine-induced renal injury in rats?

P
Population
Adult Sprague Dawley rats with experimental hyperthyroidism induced by thyroxine (T4, 100 µg/kg)
I
Intervention
Losartan (10 mg/kg), captopril (20 mg/kg), or Angiotensin 1-7 (500 µg/kg) administered for 14 days
C
Comparator
Vehicle control and thyroxine (T4) alone
O
Outcome
Creatinine clearance, protein excretion rate, glomerular volume, renal ACE1 and ACE2 protein expressionsurrogate

In a rat model of thyroxine-induced renal injury, losartan was more effective than captopril in preventing renal changes, while Angiotensin 1-7 offered no protection.

Cite This Study

Malatiali et al. (2024) studied this question.

synapsesocial.com/papers/6a8652db80e29fc8e54ca21chttps://doi.org/10.1186/s13044-024-00211-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin-Angiotensin System Contribution to Cardiac Hypertrophy in Experimental Hyperthyroidism: An Echocardiographic Study2001 · 44 citations
  2. 2Angiotensin-(1–7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice2014 · 95 citations
  3. 3Angiotensin‐(1–7) administration benefits cardiac, renal and progenitor cell function in <i>db/db</i> mice2015 · 55 citations
  4. 4Angiotensin-(1–7) and the G Protein-Coupled Receptor Mas Are Key Players in Renal Inflammation2009 · 141 citations
  5. 5Phlorizin Prevents Glomerular Hyperfiltration but not Hypertrophy in Diabetic Rats2008 · 104 citations