What question did this study set out to answer?

Evaluate the efficacy and long-term control of amiodarone hydrochloride in patients with symptomatic cardiac arrhythmias refractory to conventional antiarrhythmic drugs.

April 1, 1979Archives of Internal Medicine

Control of refractory cardiac arrhythmias with amiodarone

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Why the study?

Does amiodarone improve arrhythmia control in patients with refractory symptomatic arrhythmias?

Population

19 patients with symptomatic arrhythmias refractory to multiple antiarrhythmic drugs given to the limit of…

Design

Case_series

Follow-up

up to four years

Authors

DLD. Leak

Discussion

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Implication

Amiodarone may control refractory arrhythmias in selected patients; leaves open the need for randomized trials to establish efficacy and safety.

Key Points

Evaluate the efficacy and long-term control of amiodarone hydrochloride in patients with symptomatic cardiac arrhythmias refractory to conventional antiarrhythmic drugs.
Administered amiodarone hydrochloride to 19 patients with symptomatic supraventricular or ventricular arrhythmias resistant to multiple standard antiarrhythmic agents given to tolerance limits.
Confirmed arrhythmia control using continuous inpatient and ambulatory ECG monitoring, with patient follow-up extending up to four years.
Achieved complete arrhythmia control in 17 of 19 patients, reducing supraventricular tachycardia frequency from 7.9 attacks per month to one attack every 53.5 months.
Decreased arrhythmia-related hospital admissions from 34 in the year before treatment to zero during the year after treatment, though two patients with recurrent atrial fibrillation remained refractory.

Structured PICO

Does amiodarone improve arrhythmia control in patients with refractory symptomatic arrhythmias?

Population

19 patients with symptomatic arrhythmias (including recurrent supraventricular tachycardias, supraventricular tachycardias with Wolff-Parkinson-White syndrome, and refractory ventricular arrhythmias including recurrent ventricular tachycardia and ventricular fibrillation complicating acute coronary heart disease) refractory to multiple antiarrhythmic drugs given to the limit of tolerance.

Intervention

Amiodarone hydrochloride

Outcome

Control of arrhythmias (reduction in attacks and hospital admissions)hard clinical

Amiodarone is highly effective for controlling various refractory supraventricular and ventricular arrhythmias, significantly reducing attack frequency and hospital admissions.

Cite This Study

D. Leak (1979) studied this question.

synapsesocial.com/papers/6a865394ae12ed54832fdadc https://doi.org/10.1001/archinte.139.4.425

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Implication

Amiodarone may control refractory arrhythmias in selected patients; leaves open the need for randomized trials to establish efficacy and safety.

Control of refractory cardiac arrhythmias with amiodarone

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Control of refractory cardiac arrhythmias with amiodarone

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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