What question did this study set out to answer?

Evaluate the clinical and electrophysiological efficacy, time course of therapeutic response, and safety of oral amiodarone in patients with recurrent drug-refractory ventricular tachycardia.

January 12, 1982Acta Medica Scandinavica

Antiarrhythmic Efficacy of Amiodarone in Recurrent Ventricular Tachycardia Evaluated by Multiple Electrophysiological and Ambulatory ECG Recordings

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Why the study?

Does oral amiodarone improve arrhythmia control in patients with recurrent drug-refractory ventricular tachycardia?

Population

33 patients with recurrent drug-refractory ventricular tachycardia

Design

Case_series

Follow-up

average 6.1 months

Authors

KRKnut RasmussenLeiden University RWRoger A. WinkleElectrophysiology DRD. RossImperial College Healthcare NHS Trust

Discussion

Member takes

Implication

May control refractory VT in most patients; hypothesis-generating, needs RCTs before practice change.

Key Points

Evaluate the clinical and electrophysiological efficacy, time course of therapeutic response, and safety of oral amiodarone in patients with recurrent drug-refractory ventricular tachycardia.
Treated 33 patients with recurrent, drug-refractory ventricular tachycardia with oral amiodarone over an average follow-up of 6.1 months.
Assessed antiarrhythmic outcomes using continuous in-hospital monitoring for at least two weeks, serial electrophysiological stimulation studies, and ambulatory ECG recordings.
Maintained complete arrhythmia control in 20 of 33 patients, while 11 experienced treatment failure (10 due to documented ventricular tachycardia recurrence, with only 3 failing after the first month).
Demonstrated delayed therapeutic efficacy in 5 patients who had inadequate control between days 15 and 32 but subsequently achieved long-term suppression for 4–9 months.
Induced ventricular tachycardia during on-drug electrophysiological testing in 16 of 20 patients, 7 (44%) of whom ultimately experienced clinical treatment failure.

Structured PICO

Does oral amiodarone improve arrhythmia control in patients with recurrent drug-refractory ventricular tachycardia?

Population

33 patients with recurrent drug-refractory ventricular tachycardia

Intervention

Oral amiodarone

Outcome

Arrhythmia control evaluated by in-hospital monitoring, electrophysiological tests, and ambulatory ECGhard clinical

Oral amiodarone provides effective arrhythmia control in a majority of patients with recurrent, drug-refractory ventricular tachycardia, though full efficacy may take up to 30 days to manifest.

Cite This Study

Rasmussen et al. (1982) studied this question.

synapsesocial.com/papers/6a1bf92cc97d63156a5f2a85 https://doi.org/10.1111/j.0954-6820.1982.tb03231.x

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Antiarrhythmic Efficacy of Amiodarone in Recurrent Ventricular Tachycardia Evaluated by Multiple Electrophysiological and Ambulatory ECG Recordings

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Antiarrhythmic Efficacy of Amiodarone in Recurrent Ventricular Tachycardia Evaluated by Multiple Electrophysiological and Ambulatory ECG Recordings

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider