What does this research mean for the field?

While amiodarone is useful for treating refractory tachyarrhythmias, its efficacy in ventricular tachycardia or fibrillation is lower and its incidence of significant toxicity is higher than generally appreciated. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

To evaluate the clinical efficacy and toxicity of amiodarone in treating recurrent drug-refractory tachyarrhythmias.

July 1, 1983CirculationOpen Access

Amiodarone: clinical efficacy and toxicity in 96 patients with recurrent, drug-refractory arrhythmias.

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Why the study?

What is the clinical efficacy and toxicity of amiodarone in patients with recurrent, drug-refractory tachyarrhythmias?

Population

96 patients with recurrent, drug-refractory tachyarrhythmias

Design

Cohort

Follow-up

8.0 +/- 7.5 months (range 1 day to 27 months)

Authors

RFRichard N. FogorosDanville Community College KAKelley P AndersonUniversity of Pittsburgh RWRoger A. WinkleElectrophysiology

Discussion

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Implication

Amiodarone's long-term utility for refractory VT/VF may be more limited than assumed with high toxicity; challenges prior estimates and leaves optimal role open for prospective trials.

Key Points

To evaluate the clinical efficacy and toxicity of amiodarone in treating recurrent drug-refractory tachyarrhythmias.
Analyzed 96 patients treated with amiodarone over 8 months.
Patients categorized by type of tachyarrhythmia: VT/VF, complex ventricular ectopy, supraventricular tachyarrhythmias.
Monitored rates of successful treatment and incidence of toxicity.
52% efficacy rate at 12 months for VT/VF, decreasing to 28% at 24 months.
64.7% successful treatment for supraventricular tachyarrhythmias.
72.5% of patients experienced toxicity, with 27% having therapy-limiting side effects.

Structured PICO

What is the clinical efficacy and toxicity of amiodarone in patients with recurrent, drug-refractory tachyarrhythmias?

Population

96 patients with recurrent, drug-refractory tachyarrhythmias (77 with recurrent ventricular tachycardia or ventricular fibrillation [VT/VF], 2 with complex ventricular ectopy, and 17 with supraventricular tachyarrhythmias)

Intervention

Amiodarone

Outcome

Incidence of successful amiodarone therapy and incidence of toxicity

Amiodarone is useful for refractory tachyarrhythmias, but its long-term efficacy for VT/VF is lower and its toxicity rate is higher than previously recognized.

Cite This Study

Fogoros et al. (1983) studied this question.

synapsesocial.com/papers/6a18e0bcc9d74cf65281fbfe https://doi.org/10.1161/01.cir.68.1.88

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Implication

Amiodarone's long-term utility for refractory VT/VF may be more limited than assumed with high toxicity; challenges prior estimates and leaves optimal role open for prospective trials.

Amiodarone: clinical efficacy and toxicity in 96 patients with recurrent, drug-refractory arrhythmias.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Amiodarone: clinical efficacy and toxicity in 96 patients with recurrent, drug-refractory arrhythmias.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider