The period of hypotension following orthostatic challenge is prolonged in dementia with Lewy bodies
Why the study?
Is orthostatic hypotension more common and prolonged in patients with dementia with Lewy bodies compared to Alzheimer's disease and elderly controls?
Population
349 individuals, including 235 patients with Alzheimer's disease, 52 patients with dementia with Lewy…
Comparison
Orthostatic challenge. vs Elderly controls without cognitive impairment…
Design
Cross-sectional
Follow-up
10 minutes
Authors
Discussion
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Member takes
Implication
Supports OH screening in DLB; hypothesis-generating for outcomes and management in neurodegenerative dementias.
Structured PICO
Is orthostatic hypotension more common and prolonged in patients with dementia with Lewy bodies compared to Alzheimer's disease and elderly controls?
P
Population
349 individuals, including 235 patients with Alzheimer's disease (AD), 52 patients with dementia with Lewy bodies (DLB), and 62 elderly controls without cognitive impairment.
I
Intervention
Orthostatic challenge (standing up from supine position).
C
Comparator
Elderly controls without cognitive impairment; comparison between AD and DLB.
O
Outcome
Orthostatic hypotension (reduction of systolic blood pressure ≥20 mm Hg or diastolic blood pressure ≥10 mm Hg).surrogate
Orthostatic hypotension is significantly more common and prolonged in patients with dementia with Lewy bodies compared to those with Alzheimer's disease and elderly controls.
Cite This Study
Andersson et al. (2007) studied this question.