September 3, 2004AJP Regulatory Integrative and Comparative Physiology

Excitatory convergence of periaqueductal gray and somatic afferents in the solitary tract nucleus: role for neurokinin 1 receptors

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Population

In situ, arterially perfused, unanesthetized decerebrate rat preparation (45 NTS neurons recorded)

Design

Preclinical

Authors

PBPedro BoscanOregon National Primate Research Center JPJulian F. R. PatonGeneral Cardiology

Discussion

Member takes

Implication

NK1 antagonism attenuates NTS responses to somatic/PAG inputs in rats; leaves open translation to human cardiovascular control.

Structured PICO

Population

In situ, arterially perfused, unanesthetized decerebrate rat preparation (45 NTS neurons recorded)

Intervention

Electrical stimulation of somatic afferents (brachial plexus), cervical spinal cord, and dorsolateral periaqueductal gray (dl-PAG), with testing of NK(1) antagonist CP-99994

Outcome

NTS neuron excitation and evoked peak discharge frequencysurrogate

Somatic brachial and PAG afferents converge onto single NTS neurons via direct or indirect pathways, with NK(1) receptors activated by some of these inputs.

Cite This Study

Boscan et al. (2004) studied this question.

synapsesocial.com/papers/6a865a15bc4cc88ab5833697 https://doi.org/10.1152/ajpregu.00328.2004

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Excitatory convergence of periaqueductal gray and somatic afferents in the solitary tract nucleus: role for neurokinin 1 receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Excitatory convergence of periaqueductal gray and somatic afferents in the solitary tract nucleus: role for neurokinin 1 receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider