What question did this study set out to answer?

To review the epidemiology, clinical presentation, diagnostic approaches, and treatment strategies for disseminated histoplasmosis in individuals with acquired immune deficiency syndrome.

November 1, 1990Medicine

Disseminated Histoplasmosis in the Acquired Immune Deficiency Syndrome

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Authors

LWL. Joseph WheatIndiana Department of Natural Resources PCPatricia Connolly‐StringfieldIndiana University School of Medicine RBROBERT L. BAKERIndiana Department of Natural Resources

Discussion

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Implication

Clinical review reveals amphotericin B induction followed by maintenance therapy lowers relapse in AIDS-associated disseminated histoplasmosis, highlighting lifelong suppression needs.

Key Points

To review the epidemiology, clinical presentation, diagnostic approaches, and treatment strategies for disseminated histoplasmosis in individuals with acquired immune deficiency syndrome.
Synthesized clinical observations, diagnostic testing modalities (serologies, silver stains, and fungal cultures), and treatment protocols in patients with AIDS and disseminated Histoplasma capsulatum infection.
Evaluated clinical response and recurrence rates following induction therapy and maintenance regimens using amphotericin B versus ketoconazole.
Initial induction therapy with amphotericin B effectively reverses clinical manifestations in at least 80% of cases, though nearly all patients relapse within 1 year without ongoing maintenance.
Maintenance therapy with weekly or biweekly amphotericin B (approximately 50 mg) achieves substantially lower relapse rates (9% to 19%) compared to maintenance with ketoconazole (50% to 60%).

Cite This Study

Wheat et al. (1990) studied this question.

synapsesocial.com/papers/6a8660795dc285e07e73a703 https://doi.org/10.1097/00005792-199011000-00004

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Implication

Clinical review reveals amphotericin B induction followed by maintenance therapy lowers relapse in AIDS-associated disseminated histoplasmosis, highlighting lifelong suppression needs.

Disseminated Histoplasmosis in the Acquired Immune Deficiency Syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

Disseminated Histoplasmosis in the Acquired Immune Deficiency Syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

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