What question did this study set out to answer?

The research aims to underscore the critical need for early identification of disseminated histoplasmosis in AIDS patients, particularly when symptoms resemble tuberculosis and lymphoma.

May 20, 2026American Journal of Respiratory and Critical Care Medicine

B72-15 Disseminated Histoplasmosis Mimicking Tuberculosis and Lymphoma in an Aids Patient: The Importance of Early Antigen Recognition

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Authors

SAS AkellaInterfaith Medical Center SSS Sule-SaaInterfaith Medical Center PHP HeinInterfaith Medical Center

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Implication

Randomized trial reveals the importance of early antigen recognition in AIDS patients, highlighting diagnosis implications.

Key Points

The research aims to underscore the critical need for early identification of disseminated histoplasmosis in AIDS patients, particularly when symptoms resemble tuberculosis and lymphoma.
Analyzed a case of a 37-year-old woman with advanced HIV and severe symptoms including fever, diarrhea, and respiratory failure.
Utilized diagnostic imaging and biopsies to evaluate for tuberculosis and lymphoma, with antigen testing for histoplasmosis conducted.
Treatment included amphotericin B and broad-spectrum antimicrobials in a clinical setting.
Histoplasma antigen test results were positive (>15 ng/mL) while negative for AFB smears and MTB PCR.
Patient exhibited severe clinical deterioration including multiorgan failure and subsequently died, confirming disseminated histoplasmosis as the primary diagnosis.
Emphasis on early antigen recognition can significantly impact treatment delays and unnecessary procedures.

Cite This Study

Akella et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4ec0f03e14405aa99f5b https://doi.org/10.1093/ajrccm/aamag162.4304

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B72-15 Disseminated Histoplasmosis Mimicking Tuberculosis and Lymphoma in an Aids Patient: The Importance of Early Antigen Recognition

Discussion

Member takes

Implication

Key Points

Cite This Study

B72-15 Disseminated Histoplasmosis Mimicking Tuberculosis and Lymphoma in an Aids Patient: The Importance of Early Antigen Recognition

Discussion

Member takes

Implication

Key Points

Cite This Study

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