Resistance of Candida glabrata to drugs and the host immune system

Background: Candida glabrata is a ubiquitous organism and this species is one of the normal floras that commonly found in oral cavity, gastrointestinal and vaginal tract. However, they can be pathogenic and caused serious infection that more likely to occur in immunocompromised patients. Widespread and increased usage of immunosuppressive therapies with the additional of broad-spectrum antibiotic treatment can also lead to the significant increment of Candida infections. Candida species can cause nosocomial infection that associated with alarming high mortality rate worldwide. C. glabrata is one of the Candida species that raise an attention of a researcher due to their high resistance to certain drugs and antifungal as well as host immune system.