What question did this study set out to answer?

To evaluate the association between maternal receipt of the inactivated influenza vaccine during pregnancy and the risks of prematurity and small for gestational age births.

May 31, 2011PLoS MedicineOpen Access

Maternal Influenza Immunization and Reduced Likelihood of Prematurity and Small for Gestational Age Births: A Retrospective Cohort Study

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Authors

SOSaad B. OmerUniversity College Hospital DGDavid A. GoodmanUniversity of Essex MSMark C. SteinhoffCincinnati Children's Hospital Medical Center

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Implication

Cohort study shows reduced prematurity and small for gestational age births among infants of vaccinated mothers, highlighting the protective role of maternal influenza immunization.

Key Points

To evaluate the association between maternal receipt of the inactivated influenza vaccine during pregnancy and the risks of prematurity and small for gestational age births.
Analyzed surveillance data from the Georgia (United States) Pregnancy Risk Assessment Monitoring System for 4,326 live births between June 1, 2004, and September 30, 2006 (n=4,168 with available maternal vaccine data).
Assessed maternal receipt of inactivated influenza vaccine across any trimester relative to birth outcomes during defined influenza surveillance intervals.
Infants born during the influenza season to vaccinated mothers had lower odds of prematurity (adjusted OR = 0.60; 95% CI, 0.38-0.94), with risk reductions strengthening during local activity (adjusted OR = 0.44; 95% CI, 0.26-0.73) and widespread activity (adjusted OR = 0.28; 95% CI, 0.11-0.74).
Vaccinated mothers had 69% lower odds of delivering a small for gestational age infant during widespread influenza activity (adjusted OR = 0.31; 95% CI, 0.13-0.75), while associations before influenza season activity were not statistically significant.

Cite This Study

Omer et al. (2011) studied this question.

synapsesocial.com/papers/6a8663806b9f06dcfa3a69ea https://doi.org/10.1371/journal.pmed.1000441

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Implication

Cohort study shows reduced prematurity and small for gestational age births among infants of vaccinated mothers, highlighting the protective role of maternal influenza immunization.

Maternal Influenza Immunization and Reduced Likelihood of Prematurity and Small for Gestational Age Births: A Retrospective Cohort Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Maternal Influenza Immunization and Reduced Likelihood of Prematurity and Small for Gestational Age Births: A Retrospective Cohort Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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