Why the study?
Autonomic nerves are attractive targets for electroceutical device therapies, requiring a mechanistic understanding of multi-level organ control, disease adaptation, and neuromodulation to restore function.
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Design
Review
Electroceuticals may offer new options in HF and hypertension; leaves open mechanistic and efficacy questions for trials.
Autonomic nerves are attractive targets for medical therapies using electroceutical devices because of the potential for selective control and few side effects. These devices use novel materials, electrode configurations, stimulation patterns, and closed-loop control to treat heart failure, hypertension, gastrointestinal and bladder diseases, obesity/diabetes, and inflammatory disorders. Critical to progress is a mechanistic understanding of multi-level controls of target organs, disease adaptation, and impact of neuromodulation to restore organ function.
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Horn et al. (2019) studied this question.
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