New Dosing Regimens for Aminoglycoside Antibiotics

Editorials15 October 1992New Dosing Regimens for Aminoglycoside AntibioticsMatthew E. Levison, MDMatthew E. Levison, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-8-693 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAminoglycosides are commonly used because of their broad-spectrum and reliable antimicrobial activity against aerobic gram-negative bacilli, with fewer than 5% of strains resistant. To explain the rationale underlying the novel proposal of single daily dosing of aminoglycosides, I will describe their pharmacodynamics—the relation of the time course of their antimicrobial effect to concentrations of the antibiotic at the site of the infection (1-6).Administering the total daily dose of aminoglycoside once daily, rather than in divided doses, has recently been proposed to improve efficacy and possibly to reduce toxicity (7). Aminoglycosides have concentration-dependent bactericidal action; that is, larger doses can...References1. VogelmanGudmunssonLeggettTurnidgeEbertCraig BSJJSW. Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model. J Infect Dis. 1988;158:831-47. CrossrefMedlineGoogle Scholar2. KapusnikHackbarthChambersCarpenterSande JCHTM. Single large, daily dosing versus intermittent dosing of tobramycin for treating experimental Pseudomonas pneumonia. J Infect Dis. 1988;158:7-12. CrossrefMedlineGoogle Scholar3. 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Author, Article, and Disclosure InformationAffiliations: Medical College of Pennsylvania Philadelphia, PA 19129 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAminocyclitol AminoglycosidesAntibacterial TherapyPeritoneal infections, hernias and related complicationsINFECTIONS IN PATIENTS UNDERGOING PERITONEAL DIALYSISOnce-Daily Intraperitoneal Gentamicin is Effective Therapy for Gram-Negative Capd PeritonitisTobramycin: a review of therapeutic uses and dosing schedulesRenal InsufficiencyDrug-induced acute renal failureA randomized, prospective study comparing once-daily gentamicin versus thrice-daily gentamicin in the treatment of puerperal infectionA comparison of two amikacin dosing regimens in paediatric surgical patientsPharmacodynamics of antimicrobial therapy in surgeryPostantibiotic Effect and Virulence Factors Depression Induced by Ciprofloxacin and by Aminoglycosides in a Clinical Isolate of Pseudomonas aeruginosaEfficacy and safety of once-daily versus twice-daily netilmicin in patients with acute urinary tract infectionsANTIBACTERIAL AGENTS IN RENAL FAILUREPrevention of drug-induced nephrotoxicity in the intensive care unitPNEUMONIA IN PATIENTS WITH MULTIPLE TRAUMADrug-Induced Acute Renal FailureAntibiotic dosing in renal failureTreatment of PeritonitisLarge-dose, once daily administration of Aminoglycosides: A decades-old idea whose time is nowPeritonitisMonitoring treatment with aminoglycoside antibiotics.Monitoring treatment with aminoglycoside antibioticsMonitoring treatment with aminoglycoside antibiotics.Monitoring treatment with aminoglycoside antibiotics.Monitoring treatment with aminoglycoside antibiotics: Authors' replyElectroacupuncture in fibromyalgia: Authors' replyHIV transmission, travel and Thailand.Single Daily Dose of Aminoglycosides in the Treatment of Continuous Ambulatory Peritoneal Dialysis PeritonitisPeritoneal Infections, Hernias and Related Complications 15 October 1992Volume 117, Issue 8Page: 693-694KeywordsAntibioticsAntimicrobialsAttentionToxicity Issue Published: 15 October 1992 PDF DownloadLoading ...