Population
K562 cell lines persistently infected with vaccine strains of measles virus and mumps virus
Design
Preclinical
Follow-up
more than 6 months
Authors
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Suggests distinct mechanisms of 2-5AS suppression in persistent viral infection; leaves open relevance to human IFN responses.
The study demonstrates that persistent infection of K562 cells with measles or mumps viruses leads to decreased 2-5AS activity through different mechanisms (transcriptional suppression vs. translational failure).
Fujii et al. (1988) studied this question.
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