March 1, 1979Journal of VirologyOpen Access

Characterization of Measles Virus-Specific Proteins Synthesized In Vivo and In Vitro from Acutely and Persistently Infected Cells

View Full Paper

Ask AI

Bookmark

Population

Acutely and persistently infected cells, guinea pig immunized with measles virus, and sera from patients…

Design

Preclinical

Authors

SRShmuel RozenblattWeizmann Institute of Science MGMarian GoreckiNational Institutes of Health HSH. ShureWeizmann Institute of Science

Discussion

Member takes

Implication

Suggests M protein modification in SSPE; leaves open diagnostic or therapeutic relevance and requires clinical validation.

Structured PICO

Population

Acutely and persistently infected cells (measles virus), guinea pig(s) immunized with measles virus, and sera from patients with subacute sclerosing panencephalitis (SSPE)

Intervention

Immunoprecipitation of viral polypeptides synthesized in vivo or in vitro (reticulocyte cell-free translation system)

Outcome

Reactivity of measles viral proteins with guinea pig antimeasles virus serum and SSPE patient serasurrogate

SSPE patient sera show altered immunoreactivity to measles virus proteins, particularly lacking reactivity to the M polypeptide in cell-free translation products, suggesting modifications of measles virus proteins in SSPE.

Cite This Study

Rozenblatt et al. (1979) studied this question.

synapsesocial.com/papers/6a8a6c641fb56efa37d49c37 https://doi.org/10.1128/jvi.29.3.1099-1106.1979

View Full Paper

Ask AI

Bookmark

Characterization of Measles Virus-Specific Proteins Synthesized In Vivo and In Vitro from Acutely and Persistently Infected Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of Measles Virus-Specific Proteins Synthesized In Vivo and In Vitro from Acutely and Persistently Infected Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider