November 1, 1981Journal of General Virology
Persistent and Lytic Infections with SSPE Virus: A Comparison of the Synthesis of Virus-specific Polypeptides
Key result
Persistent SSPE virus infection in cell cultures lacked M protein synthesis compared to lytic infection, despite the presence of functional mRNA for all structural polypeptides.
Population
Cell cultures persistently infected with an isolate of measles virus from a patient with subacute sclerosing…
Comparison
Persistent infection vs Lytic infection with the homologous virus
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Does not yet guide SSPE management; leaves open post-transcriptional M protein regulation in persistent measles infection.
Structured PICO
P
Population
Cell cultures persistently infected with an isolate of measles virus from a patient with subacute sclerosing panencephalitis (SSPE)
E
Exposure
Persistent infection
C
Comparator
Lytic infection with the homologous virus
O
Outcome
Synthesis of virus-specific polypeptides and messenger RNAsurrogate
The study demonstrates that while M protein synthesis is absent in persistent SSPE virus infection, the mRNA for M protein is present and functional in vitro.
Cite This Study
Stephenson et al. (1981) studied Subacute sclerosing panencephalitis (SSPE). Persistent infection with SSPE virus vs. Lytic infection with homologous virus was evaluated on Synthesis of virus-specific polypeptides and messenger RNA. Persistent SSPE virus infection in cell cultures lacked M protein synthesis compared to lytic infection, despite the presence of functional mRNA for all structural polypeptides.