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September 1, 1973Anesthesiology

The Effects of Tidal Volume and End-expiratory Pressure on Pulmonary Gas Exchange during Anesthesia

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Why the study?

Does large-tidal-volume ventilation or continuous positive pressure improve pulmonary gas exchange compared to small tidal volume ventilation in supine adult patients undergoing general anesthesia?

Population

30 supine adult patients undergoing general anesthesia for operations on the periphery or lower abdomen

Comparison

Mechanical ventilation with a large tidal volume… vs Mechanical ventilation with a small tidal volume

Design

Other

Authors

WVWilliam D. VisickUniversity of California, San FranciscoHFH. B. FairleyUniversity of Nevada, Las VegasRHRobert F. HickeyRutgers, The State University of New Jersey

Discussion

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Implication

May improve oxygenation with larger tidal volumes under anesthesia; leaves open relevance to modern lung-protective strategies.

Structured PICO

Does large-tidal-volume ventilation or continuous positive pressure improve pulmonary gas exchange compared to small tidal volume ventilation in supine adult patients undergoing general anesthesia?

P
Population
30 supine adult patients undergoing general anesthesia for operations on the periphery or lower abdomen
I
Intervention
Mechanical ventilation with a large tidal volume or a small tidal volume with continuous positive pressure
C
Comparator
Mechanical ventilation with a small tidal volume
O
Outcome
Alveolar-arterial oxygen tension difference (A-aDo2)surrogate

Large-tidal-volume ventilation produces optimum pulmonary gas exchange in supine adult patients undergoing general anesthesia.

Cite This Study

Visick et al. (1973) studied this question.

synapsesocial.com/papers/6a86699d54e3ec4cc25af45ehttps://doi.org/10.1097/00000542-197309000-00005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Failure of Large Tidal Volumes to Improve Oxygen Availability During Anaesthesia1984 · 9 citations
  2. 2Is Positive End-expiratory Pressure Required Under General Anesthesia for Short Procedures2025
  3. 3Large Tidal Volume Ventilation Does Not Improve Oxygenation in Morbidly Obese Patients During Anesthesia1995 · 13 citations
  4. 4A Comparison of the Effects of Different Positive End-Expiratory Pressure Levels on Respiratory Parameters During Prone Positioning Under General Anaesthesia: A Randomized Controlled Trial2024 · 2 citations
  5. 5Positive end‐expiratory pressure prevents atelectasisduring general anaesthesia even in the presence of a high inspired oxygen concentration1999 · 234 citations