Why the study?
Does ventilation with large tidal volumes improve oxygen availability in patients undergoing peripheral vascular surgery?
Does ventilation with large tidal volumes improve oxygen availability in patients undergoing peripheral vascular surgery?
During anesthesia for peripheral vascular surgery, large tidal volumes do not improve oxygen availability because the increase in arterial oxygen content is offset by a reduction in cardiac output.
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Large tidal volumes should not yet change ventilation practice in vascular surgery; Level 5 data leaves open confirmation in randomized trials.
Eight patients undergoing peripheral vascular surgery were ventilated with small (5.3 ml/kg) and large (16.3 ml/kg) tidal volumes at a constant respiratory rate. Carbon dioxide was added to the inspired gases to maintain normal end-tidal levels. The use of large tidal volumes resulted in a significant increase in arterial oxygen tension and content, but, due to a reduction in cardiac output, failed to improve oxygen availability.
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Askitopoulou et al. (1984) studied this question.
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